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Griffin was born near Palos Verdes amidst the surfing culture of southern California. After attending high school, he worked on the staff of Surfer magazine where he created his surfing comic strip. In Los Angeles, Griffin met a group of artists and musicians known as the Jook Savages and participated in the Watts Acid Test held by Ken Kesey.
After seeing the psychedelic rock posters that were being designed by Stanley Mouse and Alton Kelly, Griffin and the Jook Savages decided to move to San Francisco in the fall of 1966, where he designed posters in the living room of his home on Elsie Street in the Bernal Heights district.
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In the 1970's he converted to Christianity. He published The Illustrated Book of St. John, a retelling of the Gospel of John with his unique illustrations. He also produced album art for Maranatha! Music, a Christian record label.
In 1991, Griffin was killed in a motorcycle accident in Petaluma, California.
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